|
|
| Nomenclature |
|
Symbol:
|
Tg(APP)8.9Btla
|
|
Name:
|
transgene insertion 8.9, Bruce Lamb
|
|
MGI ID: |
MGI:2447591 |
|
Synonyms: |
APPYAC, hABetaPP, hAPP-YAC, Py8.9, Tg(APP)C9.24Jgh |
|
Transgene:
|
Tg(APP)8.9Btla
Location:
unknown
|
|
Transgene
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:80947
|
|
Parent Cell Line:
| D3 (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A 650 kb YAC containing the entire human APP gene and 350 kb of flanking sequence was randomly integerated into ES cells. Southern blot analysis confirmed that construct rearrangement did not occur and that the animals carried a single copy of the intact transgene. Quantitative RT-PCR analysis of transgenic and wild-type mice revealed that the levels of transgenic human alternate transcripts corresponded with those of the endogenous alternative transcripts. The human APP promoter drives expression in the brain, heart, kidney and testes. (J:80947)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:80947
Lamb BT et al.,
"Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]"
Nat Genet 1993 Sep;5(1):22-30
|
|
All: |
12 reference(s)
|
|
Analysis Tools
