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| Nomenclature |
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Symbol:
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Tg(MT-HGFSF)18Lmb
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Name:
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transgene insertion 18, Glenn Merlino
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MGI ID: |
MGI:2447463 |
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Synonyms: |
MT-HGF/SF, SF/HGF, Tg HFG |
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Transgene:
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Tg(Mt-HGFSF)18Lmb
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene consists of a mouse metallothionein 1 promoter, the entire mouse hepatocyte growth factor cDNA sequence, a human growth hormone polyadenylation site, and mouse Mt1 5' and 3' flanking regions. Northern blot analysis showed transgene expression in all adult transgenic tissues examined. ELIZA assay showed overexpression of transgene product in urine and serum samples. (J:34022)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Nine founders carrying between 7-27 copies of the transgene were created. Transgenic animals over-expressed the transgene 3-fold to 50-fold. The line 18 transgene, Tg(Mt-HGFSF)18Lmb, is also called MT-HGF/SF.
Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)
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| References |
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Original: |
J:34022
Takayama H et al.,
"Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development."
Proc Natl Acad Sci U S A 1996 Jun 11;93(12):5866-71
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All: |
14 reference(s)
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Analysis Tools
