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| Nomenclature |
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Symbol:
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Tg(PSEN1)S8-4Dbo
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Name:
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transgene insertion S8-4, David R Borchelt
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MGI ID: |
MGI:2447452 |
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Synonyms: |
S8-4, Tg(PSEN1)1Dbo, wildtype Hu PS1 |
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Transgene:
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Tg(PSEN1)S8-4Dbo
Location:
unknown
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene consists of a mouse prion promoter and a cDNA encoding wild-type human presenilin 1. Transgene expression was verified by Northern and Western blot analysis of brain extracts derived from transgenic animals. Lines S8-4, R8-1, H8-4, and B8-1 were generated. (J:34323)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Several transgenic lines were created. S8-4 is one of the highest expressing lines.
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| References |
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Original: |
J:34323
Thinakaran G et al.,
"Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo."
Neuron 1996 Jul;17(1):181-90
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All: |
8 reference(s)
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Analysis Tools
