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| Nomenclature |
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Symbol:
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Tg(PSEN1)5Dbo
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Name:
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transgene insertion 5, David R Borchelt
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MGI ID: |
MGI:2447335 |
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Synonyms: |
APP/PS1, Hu PS1-A246E, PS1A246E, PS1 A246E, PS1-A246E, PS1/A246E, Tg(PSEN1*A246E)5Dbo |
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Transgene:
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Tg(PSEN1)5Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene consists of a mouse prion promoter and a cDNA encoding human presenilin 1 bearing the A246E substitution found in familial Alzheimer's disease (FAD). Transgene expression was verified by Northern and Western blot analysis of brain extracts derived from transgenic animals. (J:80882)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This line was generated from founder number N-5.
Transgenic mice that are also transgenic for Tg(APP695)3Dbo
express both human presenilin 1 (A246E variant) and a chimeric amyloid precursor protein (APPSwe) under direction of the mouse prion protein promoter. Elevated levels of the AB1-42(43) peptide are detected in brain homogenates. By nine months of age, histological examination of brain tissue from these mice reveals numerous amyloid deposits resembling those observed in the brains of patients with Alzheimer's disease (AD). The number of amyloid deposits increases dramatically between the ages of 10 and 12 months.
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| References |
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Original: |
J:80882
Borchelt DR et al.,
"Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo."
Neuron 1996 Nov;17(5):1005-13
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All: |
47 reference(s)
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Analysis Tools
