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| Nomenclature |
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Symbol:
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Tg(PDGFB-PSEN1M146L)2Jhd
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Name:
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transgene insertion 2, John Hardy
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MGI ID: |
MGI:2447326 |
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Synonyms: |
PDGF-hPS1, PS1M146L, PS1(M146L), PS1mut, PS1 Tg line 6.2, PSlM146L |
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Transgene:
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Tg(PDGFB-PSEN1M146L)2Jhd
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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SW x (C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A PDGFB promoter fused to a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to leucine substitution at amino acid 146 (M146L), was used for the transgene. The PDGFB promoter was used to drive transgene expression in neurons. Transgene expression was confirmed by Northern and Western blot analysis of brain extracts derived from transgenic animals. (J:80861)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:80861
Duff K et al.,
"Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1."
Nature 1996 Oct 24;383(6602):710-3
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All: |
62 reference(s)
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Analysis Tools
