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| Nomenclature |
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Symbol:
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Arhgap6/Hccs/Mid1tm1Hzo
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Name:
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midline 1;
targeted mutation 1, Huda Y Zoghbi
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MGI ID: |
MGI:2447298 |
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Synonyms: |
Mid1tm1Hzo, MLS2loxP |
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Gene:
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Mid1
Location:
ChrX:169685199-169990798 bp, + strand
Genetic Position: ChrX,
79.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:80528
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Intergenic deletion |
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Mutation details: The gene was replaced by a puromycin resistance gene and a loxP site in ES cells in which Arhgap6 had already been subjected to targeted mutation to replace exons 6, 7, and 8 with a neomycin resistance cassette and a loxP site. The two loxP sites are situated so that cre excision eliminates both resistance genes and all intervening DNA. All of Mid1, the entire Hccs gene, and all of Arhgap6 3' of exon 5 are thus conditionally deleted. (J:80528)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:80528
Prakash SK et al.,
"Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant micro-phthalmia with linear skin defects (MLS) syndrome."
Hum Mol Genet 2002 Dec 1;11(25):3237-48
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All: |
1 reference(s)
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Analysis Tools
