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| Nomenclature |
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Symbol:
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Blnktm1Pjln
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Name:
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B cell linker;
targeted mutation 1, Peter J Nielsen
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MGI ID: |
MGI:2447161 |
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Synonyms: |
Slp65-, SLP-65- |
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Gene:
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Blnk
Location:
Chr19:40928927-40994535 bp, - strand
Genetic Position: Chr19,
34.26 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58740
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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BALB/c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 4 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of splenocyte RNA revealed low levels of an aberrantly spliced transcript, however Western blot analysis detected no protein product. (J:58740)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Blnk Mutation:
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51 strains or lines available |
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| References |
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Original: |
J:58740
Jumaa H et al.,
"Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65."
Immunity 1999 Nov;11(5):547-54
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All: |
20 reference(s)
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Analysis Tools
