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| Nomenclature |
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Symbol:
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Tg(Thy1-APP)3Somm
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Name:
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transgene insertion 3, Bernd Sommer
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MGI ID: |
MGI:2447146 |
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Synonyms: |
APP23, APP 23, TgAPP23, Tg(Thy1-APP)23/1Npa, Tg(Thy1APP)23Sdz, Tg(Thy1-APPK670N;M671L) |
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Transgene:
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Tg(Thy1-APP)3Somm
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A mouse Thy1 promoter and a human APP751 cDNA sequence carrying the Swedish double mutation K670N and M671L found in Alzheimer's disease patients was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus. (J:44603)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
The transgene was determined to be 7-fold over-expressed.
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| References |
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Original: |
J:44603
Sturchler-Pierrat C et al.,
"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology."
Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13287-92
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All: |
90 reference(s)
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Analysis Tools
