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| Nomenclature |
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Symbol:
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Tg(Prnp)a20Cwe
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Name:
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transgene insertion a20, Charles Weissmann
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MGI ID: |
MGI:2447133 |
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Synonyms: |
tg20, Tg-20, tga20 |
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Transgene:
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Tg(Prnp)a20Cwe
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene encodes a wild-type mouse prion protein. Expression studies demonstrated that this line expresses Prnp transcripts in the brain 6- to 7-fold compared to wild-type. Expression patterns were similar to those of wild-type mice with the notable exception that transcript was not detected in Purkinje cells. This transgenic construct, referred to as 'half genomic,' was designed to omit a large intron in order to facilitate subsequent mutagenesis studies. (J:32214)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:32214
Fischer M et al.,
"Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie."
EMBO J 1996 Mar 15;15(6):1255-64
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All: |
52 reference(s)
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Analysis Tools
