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| Nomenclature |
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Symbol:
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Tg(Tagln-cre)1Her
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Name:
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transgene insertion 1, Joachim Herz
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MGI ID: |
MGI:2446975 |
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Synonyms: |
SM, SM22a-Cre, Sm22alphaCre, SM22-Cre, SM22-Cretg, Tag1-Cre, Tgln-Cre |
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Transgene:
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Tg(Tagln-cre)1Her
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgene consists of a Tagln promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells. (J:76460)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:76460
Holtwick R et al.,
"Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure."
Proc Natl Acad Sci U S A 2002 May 14;99(10):7142-7
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All: |
61 reference(s)
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Analysis Tools
