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| Nomenclature |
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Symbol:
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Cyr61tm1Lfl
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Name:
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cysteine rich protein 61;
targeted mutation 1, Lester F Lau
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MGI ID: |
MGI:2446577 |
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Synonyms: |
Ccn1-, Cyr61- |
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Gene:
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Cyr61
Location:
Chr3:145646971-145649985 bp, - strand
Genetic Position: Chr3,
70.18 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:80618
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: All of exon 1 and a portion of exon 2 were replaced by a cassette inserted by homologous recombination and containing lacZ and neo. In addition to deleting endogenous sequence, the insertion of the cassette shifted downstream sequence out of frame. Expression analysis of embryonic fibroblasts derived from homozygous mutant mice indicated an absence of both transcript and protein, even after serum stimulation. Expression of lacZ was determined to be driven by the endogenous promoter. (J:80618)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cyr61 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:80618
Mo FE et al.,
"CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity."
Mol Cell Biol 2002 Dec;22(24):8709-20
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All: |
2 reference(s)
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Analysis Tools
