|
|
| Nomenclature |
|
Symbol:
|
Slc6a3tm2Mca
|
|
Name:
|
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3;
targeted mutation 2, Marc G Caron
|
|
MGI ID: |
MGI:2446518 |
|
Synonyms: |
DAT-KD |
|
Gene:
|
Slc6a3
Location:
Chr13:73536747-73578672 bp, + strand
Genetic Position: Chr13,
40.1 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:67549
|
|
Parent Cell Line:
| W9.5/W95 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A hypomorphic allele was generated by the insertion of a cassette containing tTA, PGK-neo, and tetO immediately upstream of the start codon. While expression of tTA was not detected, putatively due to an influence of the PGK promoter, Western blot analysis of homozygous mutant mice showed that the presence of the cassette reduced protein levels by approximately 90% in the striatum. (J:67549)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Slc6a3 Mutation:
|
32 strains or lines available |
|
| References |
|
Original: |
J:67549
Zhuang X et al.,
"Hyperactivity and impaired response habituation in hyperdopaminergic mice."
Proc Natl Acad Sci U S A 2001 Feb 13;98(4):1982-7
|
|
All: |
12 reference(s)
|
|
Analysis Tools
