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| Nomenclature |
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Symbol:
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Etv4tm1Hass
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Name:
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ets variant gene 4 (E1A enhancer binding protein, E1AF);
targeted mutation 1, John A Hassell
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MGI ID: |
MGI:2445834 |
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Synonyms: |
PEA3-, PEA3-null |
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Gene:
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Etv4
Location:
Chr11:101769747-101785371 bp, - strand
Genetic Position: Chr11,
65.48 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66012
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence extending from within exon 6 through exon 11, including the region encoding the ETS DNA binding domain, was replaced with a neomycin selection cassette inserted by homologous recombination. Though no normal or endogenous alternatively spliced transcripts were detected in homozygous mutant mice, a stable transcript corresponding to the targeted allele was identified by RNAse protection. Normal protein was undetected by Western blot analysis of MEFs, however, the lack of an amino-terminal antibody prevented the ruling out of the presence of a truncated protein. (J:66012)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Etv4 Mutation:
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19 strains or lines available |
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| References |
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Original: |
J:66012
Laing MA et al.,
"Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene"
Mol Cell Biol 2000 Dec;20(24):9337-45
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All: |
4 reference(s)
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Analysis Tools
