|
|
| Nomenclature |
|
Symbol:
|
Tg(Prnp-tTA)F959Sbp
|
|
Name:
|
transgene insertion F959, Stanley B Prusiner
|
|
MGI ID: |
MGI:2445786 |
|
Synonyms: |
Tg(Prnp-tTA/F959), Tg(Prnp-tTA)FV |
|
Transgene:
|
Tg(Prnp-tTA)F959Sbp
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
FVB.129S7(B6)-Prnptm1Cwe/J
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A tet transactivator gene under the control of a mouse Prnp promoter was used for the transgene. The mouse Prnp promoter targets transgene expression to the brain. High levels of transgene expression was observed in the cortex and hippocampus, and lower levels were observed in thalamic, hypothalamic, and brainstem regions via mRNA in situ hybridization. (J:50359)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
This transgene was originally microinjected into Prnptm1Cwe oocytes. Founder F973 exhibits the highest level of transgene expression, followed by founders F959 and F966.
|
| References |
|
Original: |
J:50359
Tremblay P et al.,
"Doxycycline control of prion protein transgene expression modulates prion disease in mice."
Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12580-5
|
|
All: |
9 reference(s)
|
|
Analysis Tools
