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| Nomenclature |
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Symbol:
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Mmp14tm1Hbh
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Name:
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matrix metallopeptidase 14 (membrane-inserted);
targeted mutation 1, Henning Birkedal-Hansen
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MGI ID: |
MGI:2445723 |
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Synonyms: |
MT1-, Mt1-MMP |
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Gene:
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Mmp14
Location:
Chr14:54431604-54441258 bp, + strand
Genetic Position: Chr14,
27.79 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57969
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encompassing exons 2 through 5, encoding amino acids 6 through 274, was replaced when a PGK-hprt cassette was inserted at the endogenous locus via homologous recombination. The deleted region included all but 5 residues of the prodomain and 8 residues of the catalytic domain. Northern blot analysis using probes for the amino- and carboxyl-terminal untargeted regions indicated a complete absence of transcript produced from the targeted allele. (J:57969)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mmp14 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:57969
Holmbeck K et al.,
"MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover."
Cell 1999 Oct 1;99(1):81-92
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All: |
22 reference(s)
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Analysis Tools
