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| Nomenclature |
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Symbol:
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Tg(Scgb1a1-rtTA)1Jaw
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Name:
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transgene insertion 1, Jeffrey A Whitsett
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MGI ID: |
MGI:2445707 |
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Synonyms: |
CC10-rtTA, CCSP-rtTA, CCSPtg, Scgb1a1-rtTA, Tg(Ugb-rtTA)1Jaw |
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Transgene:
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Tg(Scgb1a1-rtTA)1Jaw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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129 and C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene is composed of 2.3 kb of rat Ugb (Scgb1a1) promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and 2 kb of human growth hormone sequences, which includes introns and a polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The rat Scgb1a1 promoter is active in respiratory epithelial cells. (J:61736)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523, J:171488).
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| References |
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Original: |
J:61736
Tichelaar JW et al.,
"Conditional expression of fibroblast growth factor-7 in the developing and mature lung."
J Biol Chem 2000 Apr 21;275(16):11858-64
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All: |
104 reference(s)
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Analysis Tools
