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| Nomenclature |
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Symbol:
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Gja5tm1Paul
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Name:
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gap junction protein, alpha 5;
targeted mutation 1, David L Paul
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MGI ID: |
MGI:2445466 |
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Synonyms: |
Cx40- |
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Gene:
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Gja5
Location:
Chr3:97032416-97053634 bp, + strand
Genetic Position: Chr3,
42.04 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46430
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The single coding exon of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of frozen heart sections from homozygous mutant animals. (J:46430)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gja5 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:46430
Simon AM et al.,
"Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block."
Curr Biol 1998 Feb 26;8(5):295-8
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All: |
24 reference(s)
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Analysis Tools
