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| Nomenclature |
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Symbol:
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Ikbkbtm2Mka
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Name:
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inhibitor of kappaB kinase beta;
targeted mutation 2, Michael Karin
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MGI ID: |
MGI:2445462 |
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Synonyms: |
Ikbk2fx, IkkBetaF, IKKbeta flox, IkkbetaloxP |
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Gene:
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Ikbkb
Location:
Chr8:22659212-22706589 bp, - strand
Genetic Position: Chr8,
11.42 cM, cytoband A3-A4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:80159
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted that flank exon 3, which encodes the ATP binding site of the catalytic domain. An adjacent neomycin selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. (J:82995)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ikbkb Mutation:
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10 strains or lines available |
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Notes |
ES cell line = GS (Genome Systems).
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| References |
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Original: |
J:80159
Park JM et al.,
"Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition."
Science 2002 Sep 20;297(5589):2048-51
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All: |
56 reference(s)
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Analysis Tools
