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| Nomenclature |
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Symbol:
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Pax8tm1(cre)Mbu
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Name:
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paired box gene 8;
targeted mutation 1, Meinrad Busslinger
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MGI ID: |
MGI:2445461 |
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Synonyms: |
Pax8-, Pax8neo |
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Gene:
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Pax8
Location:
Chr2:24420551-24475599 bp, - strand
Genetic Position: Chr2,
16.43 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:80208
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 3 with an in-frame cre recombinase and frt-flanked neo cassette via homologous recombination. The targeted mutation deletes the N-terminal portion of the paired domain, which is essential for DNA-binding. (J:80208)
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Recombinase activity
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Driver:
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Pax8
Summary of all recombinase alleles
driven by Pax8.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pax8 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:80208
Bouchard M et al.,
"Nephric lineage specification by Pax2 and Pax8."
Genes Dev 2002 Nov 15;16(22):2958-70
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All: |
7 reference(s)
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Analysis Tools
