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| Nomenclature |
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Symbol:
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Tg(GFAP-TAg121)1Tvd
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Name:
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transgene insertion 1, Terry Van Dyke
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MGI ID: |
MGI:2445447 |
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Synonyms: |
GdeltaZT121, G(deltaZ)T121, TgG(deltaZ)T121, Tg(GFAP-SV40T)2.1Tvd, Tg(GFAP-T121)2.1Tvd |
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Transgene:
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Tg(GFAP-TAg121)1Tvd
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This allele was derived from mating Tg(GFAP-lacZ-TAg121)92Tvd animals to mice carrying a cre transgene (Tg(ACTB-cre)2Mrt). As a result the intervening floxed lacZ cassette was removed, leaving a single loxP site and allowing transcription from the mutant SV40 T antigen sequence. The mutant SV40 T antigen 121 contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. The mutant antigen binds RB1/RBL1/RBL2 but not TRP53. Immunohistochemical analysis of progeny showed diffuse expression of this transgene throughout the brain. (J:77132)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Astrocytoma (J:77132, J:99385)
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| References |
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Original: |
J:77132
Xiao A et al.,
"Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation."
Cancer Cell 2002 Mar;1(2):157-68
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All: |
5 reference(s)
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Analysis Tools
