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| Nomenclature |
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Symbol:
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Tg(GFAP-SV40T)1Tvd
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Name:
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transgene insertion 1, Terry Van Dyke
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MGI ID: |
MGI:2445446 |
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Synonyms: |
TgGFAPT121, TgGFAP-T121, Tg(GFAP-T121)1Tvd |
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Transgene:
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Tg(GFAP-SV40T)1Tvd
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene consists of a 2.2 kb fragment of human GFAP promoter, active in central nervous system cells of the astrocyte lineage, and a mutant SV40 T antigen sequence, which contains a deletion for the small t antigen-specific splice signal and a deletion resulting in truncation of the large T antigen at amino acid 121. Transgene expression in central nervous system cells of the astrocyte lineage was observed by immunohistochemical staining of brain sections from transgenic animals. (J:77132)
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
10 out of 13 founder animals developed severe brain abnormalities and died by 7-9 days of age. This transgene differs from Tg(GFAP-TAg121)1Tvd, which is a derivative of Tg(GFAP-lacZ-TAg121)92Tvd, and contains a loxP site in place of a Cre deleted lacZ cassette.
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| References |
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Original: |
J:77132
Xiao A et al.,
"Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation."
Cancer Cell 2002 Mar;1(2):157-68
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All: |
1 reference(s)
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Analysis Tools
