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| Nomenclature |
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Symbol:
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Hbb-artm2Mkg
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Name:
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hemoglobin, activating region;
targeted mutation 2, Mark Groudine
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MGI ID: |
MGI:2445411 |
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Synonyms: |
deltaHS2+neo |
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Gene:
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Hbb-ar
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28981
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Parent Cell Line:
| AK7 (ES Cell) |
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Strain of Origin:
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129S4/SvJaeSor
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: A 1.1 kb genomic region containing the 5' DNase hypersensitive site 2 (HS2) was replaced with an FRT-flanked PGK-neo cassette via homologous recombination. Successful gene targeting was confirmed by Southern blot analysis of mutant animals. (J:28981)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hbb-ar Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:28981
Fiering S et al.,
"Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus."
Genes Dev 1995 Sep 15;9(18):2203-13
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All: |
1 reference(s)
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Analysis Tools
