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| Nomenclature |
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Symbol:
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Nr3c2tm1Gsc
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Name:
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nuclear receptor subfamily 3, group C, member 2;
targeted mutation 1, Gunther Schutz
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MGI ID: |
MGI:2441654 |
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Synonyms: |
MR- |
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Gene:
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Nr3c2
Location:
Chr8:76899442-77245012 bp, + strand
Genetic Position: Chr8,
36.34 cM
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Histological and immunocytochemical kidney analysis of Nr3c2tm1Gsc/Nr3c2tm1Gsc mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77285
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: The majority of exon 3, which encodes the first zinc finger of the DNA binding domain, was replaced with a cassette containing lacZ and neo. RT-PCR showed the presence of a fusion transcript containing lacZ in place of endogenous exon 3 sequence. (J:77285)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nr3c2 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:77285
Berger S et al.,
"Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism."
Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9424-9
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All: |
6 reference(s)
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Analysis Tools
