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| Nomenclature |
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Symbol:
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Gyktm1Wjc
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Name:
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glycerol kinase;
targeted mutation 1, William J Craigen
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MGI ID: |
MGI:2429928 |
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Gene:
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Gyk
Location:
ChrX:85701937-85776819 bp, - strand
Genetic Position: ChrX,
39.32 cM, cytoband C-D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43449
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encompassing all of exons 13 and 14 as well as a portion of exon 15 was replaced with a neomycin selection cassette. mRNA was undetected by Northern blot analysis of liver tissue obtained from homozygous mutant mice. A biochemical assay showed glycerol kinase activity to be reduced by over 95% in liver, kidney, and brown fat. (J:43449)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gyk Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:43449
Huq AH et al.,
"X-linked glycerol kinase deficiency in the mouse leads to growth retardation, altered fat metabolism, autonomous glucocorticoid secretion and neonatal death."
Hum Mol Genet 1997 Oct;6(11):1803-9
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All: |
6 reference(s)
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Analysis Tools
