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| Nomenclature |
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Symbol:
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Glb1tm1Jmat
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Name:
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galactosidase, beta 1;
targeted mutation 1, Junichiro Matsuda
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MGI ID: |
MGI:2429923 |
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Synonyms: |
betaGal- |
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Gene:
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Glb1
Location:
Chr9:114401119-114474377 bp, + strand
Genetic Position: Chr9,
64.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43534
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: Exon 15 was disrupted by the insertion of a neomycin selection cassette. Only residual beta-galactosidase activity was detected in brain tissue obtained from homozygous mutant mice. Higher levels of residual activity were observed in spleen, testes, and renal tissues. (J:43534)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Glb1 Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:43534
Matsuda J et al.,
"Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis."
Glycoconj J 1997 Sep;14(6):729-36
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All: |
7 reference(s)
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Analysis Tools
