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| Nomenclature |
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Symbol:
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Dvl2tm1Awb
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Name:
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dishevelled 2, dsh homolog (Drosophila);
targeted mutation 1, Anthony Wynshaw-Boris
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MGI ID: |
MGI:2429760 |
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Synonyms: |
Dvl2- |
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Gene:
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Dvl2
Location:
Chr11:70000595-70012301 bp, + strand
Genetic Position: Chr11,
42.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79834
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette inserted by homologous recombination replaced a portion of exon 2 and all of exons 3 through 6. Western blot analysis of homozygous mutant brain lysates indicated an absence of protein. (J:79834)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79834
Hamblet NS et al.,
"Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure."
Development 2002 Dec;129(24):5827-38
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All: |
10 reference(s)
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Analysis Tools
