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| Nomenclature |
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Symbol:
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Tg(MMTV-TGFBR2)7Hlm
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Name:
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transgene insertion 7, Harold L Moses
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MGI ID: |
MGI:2429406 |
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Synonyms: |
MMTV-DNIIR-7, TGF-betaRIIDN |
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Transgene:
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Tg(MMTV-TGFBR2)7Hlm
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A human cDNA encoding a carboxy-terminally truncated TGFBR2 was adjoined to an MMTV regulatory region. While the encoded receptor contains the complete extracellular and transmembrane domains and is therefore capable of ligand binding and and interacting with type 1 receptors, it lacks the kinase domain. Expression was driven in mammary epithelial cells by the MMTV LTR promoter/enhancer. Transgenic expression was verified by Northern blot analysis. (J:46432)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:46432
Gorska AE et al.,
"Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice."
Cell Growth Differ 1998 Mar;9(3):229-38
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All: |
4 reference(s)
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Analysis Tools
