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| Nomenclature |
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Symbol:
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Krt14tm1Efu
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Name:
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keratin 14;
targeted mutation 1, Elaine Fuchs
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MGI ID: |
MGI:2429386 |
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Synonyms: |
K14 - |
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Gene:
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Krt14
Location:
Chr11:100203162-100207548 bp, - strand
Genetic Position: Chr11,
63.43 cM, cytoband D
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Krt14tm1Efu/Krt14tm1Efu mice exhibit gross blistering over body surface
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:25763
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The endogenous gene was disrupted by the insertion of a cassette containing human vimetin (VIM) sequence followed by growth hormone sequence and PGK-neo. Though the VIM sequence was inserted at the endogenous start codon, the transgene was not expressed. Northern and Western blot analyses indicated an absence of both endogenous transcript and protein in homozygous mutant mice. (J:25763)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Krt14 Mutation:
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20 strains or lines available |
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| References |
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Original: |
J:25763
Lloyd C et al.,
"The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14."
J Cell Biol 1995 Jun;129(5):1329-44
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All: |
4 reference(s)
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Analysis Tools
