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| Nomenclature |
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Symbol:
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Sncatm1Nbm
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Name:
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synuclein, alpha;
targeted mutation 1, Robert L Nussbaum
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MGI ID: |
MGI:2389489 |
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Synonyms: |
Scna-, Snca- |
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Gene:
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Snca
Location:
Chr6:60731573-60829855 bp, - strand
Genetic Position: Chr6,
29.15 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79784
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4 and 5 were replaced with a neomycin selection cassette inserted by homologous recombination. While the separation of Western blot results by 2D-PAGE showed various isoforms in total brain extract obtained from wild-type mice, protein was undetected in samples obtained from homozygous mutant mice. (J:79784)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79784
Cabin DE et al.,
"Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein."
J Neurosci 2002 Oct 15;22(20):8797-807
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All: |
15 reference(s)
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Analysis Tools
