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| Nomenclature |
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Symbol:
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Mt3tm1Rpa
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Name:
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metallothionein 3;
targeted mutation 1, Richard D Palmiter
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MGI ID: |
MGI:2389488 |
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Synonyms: |
Mt3- |
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Gene:
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Mt3
Location:
Chr8:94152607-94154148 bp, + strand
Genetic Position: Chr8,
46.29 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38222
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 2.2 kb of sequence, encompassing the promoter and exons 1 and 2, was replaced by a neomycin selection cassette. Quantitative solution hybridization showed an absence of transcript in samples derived from homozygous mutant mice. (J:38222)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:38222
Erickson JC et al.,
"Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures."
J Neurosci 1997 Feb 15;17(4):1271-81
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All: |
10 reference(s)
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Analysis Tools
