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| Nomenclature |
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Symbol:
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Blnktm1Achn
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Name:
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B cell linker;
targeted mutation 1, Andrew C Chan
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MGI ID: |
MGI:2389137 |
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Synonyms: |
BLNK- |
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Gene:
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Blnk
Location:
Chr19:40928927-40994535 bp, - strand
Genetic Position: Chr19,
34.26 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58805
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 1 was disrupted by homologous recombination of a construct containing GFP, a floxed neo gene, and a mutated start codon (ATC). While the GFP coding region was linked to its own Kozak sequence and start codon, fluorescence was undetected in splenocytes and bone marrow cells derived from heterozygous mutant mice. Immunoblot analysis on homozygote bone marrow cells failed to detect Blnk protein. (J:58805)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:58805
Pappu R et al.,
"Requirement for B cell linker protein (BLNK) in B cell development."
Science 1999 Dec 3;286(5446):1949-54
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All: |
7 reference(s)
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Analysis Tools
