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| Nomenclature |
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Symbol:
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Nfatc4tm1Jmk
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Name:
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nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4;
targeted mutation 1, Jeffery D Molkentin
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MGI ID: |
MGI:2388915 |
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Gene:
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Nfatc4
Location:
Chr14:55824795-55833943 bp, + strand
Genetic Position: Chr14,
28.19 cM, cytoband C1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79608
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 3 through 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the Rel homology domain. Neither transcript nor protein was detected in cardiac tissue obtained from homozygous mutant mice. (J:79608)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79608
Wilkins BJ et al.,
"Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth."
Mol Cell Biol 2002 Nov;22(21):7603-13
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All: |
4 reference(s)
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Analysis Tools
