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| Nomenclature |
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Symbol:
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Tnftm2Gkl
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Name:
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tumor necrosis factor;
targeted mutation 2, George Kollias
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MGI ID: |
MGI:2388715 |
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Synonyms: |
TNFdeltaARE |
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Gene:
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Tnf
Location:
Chr17:35199381-35202007 bp, - strand
Genetic Position: Chr17,
18.59 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54056
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: 69 bp encompassing the AU-rich elements (ARE) were deleted by homologous recombination of a floxed neo cassette and subsequent in vitro cre mediated excision. The resultant allele contained a single loxP site in place of the ARE sequence. ELISA of homozygous mutant mice showed protein levels higher than in wild-type mice, indicating a suppressive role of the AREs. (J:54056)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease when heterozygote, homozygote, or compound heterozygote with Tnftm1Gkl (J:54056) (J:136667).
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| References |
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Original: |
J:54056
Kontoyiannis D et al.,
"Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies."
Immunity 1999 Mar;10(3):387-98
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All: |
20 reference(s)
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Analysis Tools
