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| Nomenclature |
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Symbol:
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Dlx5/Dlx6tm1Tlu
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Name:
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distal-less homeobox 5;
targeted mutation 1, Thomas Lufkin
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MGI ID: |
MGI:2388595 |
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Synonyms: |
Dlx5/6-, Dlx5/6lacZ, Dlx6/Dlx5tm1Tlu, Dlx6lacZ |
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Gene:
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Dlx5
Location:
Chr6:6877805-6882085 bp, - strand
Genetic Position: Chr6,
2.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76480
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: An 11 kb genomic region spanning the homeoboxes of Dlx6 and Dlx5 was deleted and replaced with a lacZ-neo cassette using a single homologous recombination event. Absence of gene expression was confirmed by whole mount in situ hybridization of day E10.5 homozgyous mutant embryos. (J:76480)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dlx5 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:76480
Robledo RF et al.,
"The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development."
Genes Dev 2002 May 1;16(9):1089-101
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All: |
6 reference(s)
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Analysis Tools
