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| Nomenclature |
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Symbol:
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Tg(MtTGFA)42Lmb
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Name:
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transgene insertion 42, Glenn Merlino
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MGI ID: |
MGI:2388567 |
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Synonyms: |
line MT42, MT42, MT-TGF-alpha, MT/TGF-alpha line MT42, TGF-alpha, Tg(Mt1-TGFA)42Lmb |
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Transgene:
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Tg(MtTGFA)42Lmb
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Tg(MtTGFA)100Lmb). (J:28452)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:28452
Jhappan C et al.,
"TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas."
Cell 1990 Jun 15;61(6):1137-46
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All: |
29 reference(s)
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Analysis Tools
