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| Nomenclature |
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Symbol:
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Kcnj1tm1Ges
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Name:
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potassium inwardly-rectifying channel, subfamily J, member 1;
targeted mutation 1, Gary E Shull
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MGI ID: |
MGI:2388372 |
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Synonyms: |
Romk-, ROMK(-) |
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Gene:
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Kcnj1
Location:
Chr9:32372418-32399192 bp, + strand
Genetic Position: Chr9,
17.69 cM
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Kcnj1tm1Ges/Kcnj1tm1Ges mice exhibit hydronephrosis
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79354
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The exon encoding the majority the 391 amino acid protein product was disrupted by the insertion of a neomycin selection cassette. While normal transcript was undetected by Northern blot analysis of homozygous mutant mice, trace levels of an elongated transcript were detected with a 3' probe. (J:79354)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79354
Lorenz JN et al.,
"Impaired Renal NaCl Absorption in Mice Lacking the ROMK Potassium Channel, a Model for Type II Bartter's Syndrome."
J Biol Chem 2002 Oct 4;277(40):37871-80
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All: |
7 reference(s)
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Analysis Tools
