|
|
| Nomenclature |
|
Symbol:
|
Scd1tm1Ntam
|
|
Name:
|
stearoyl-Coenzyme A desaturase 1;
targeted mutation 1, James M Ntambi
|
|
MGI ID: |
MGI:2388371 |
|
Synonyms: |
SCD1- |
|
Gene:
|
Scd1
Location:
Chr19:44394451-44407709 bp, - strand
Genetic Position: Chr19,
37.98 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:71350
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The entire coding region of the gene (exons 1-6) was replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of various tissue samples and by Western blot analysis of liver protein extracts. Enzyme activity was also undetectable in liver extracts from homozygous animals. (J:71350)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:71350
Miyazaki M et al.,
"Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid."
J Nutr 2001 Sep;131(9):2260-8
|
|
All: |
24 reference(s)
|
|
Analysis Tools
