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| Nomenclature |
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Symbol:
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Hmox1tm1Poss
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Name:
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heme oxygenase (decycling) 1;
targeted mutation 1, Kenneth D Poss
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MGI ID: |
MGI:2388322 |
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Synonyms: |
Hmox1-, HO-1-, HO1- |
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Gene:
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Hmox1
Location:
Chr8:75093591-75100596 bp, + strand
Genetic Position: Chr8,
35.59 cM, cytoband C1
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Iron-loading of Hmox1tm1Poss/Hmox1tm1Poss tissues.
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79254
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3.7 kb fragment encompassing exons 3, 4, and a portion of 5 was replaced with a neomycin selection cassette. The deleted region consisted of approximately 85% of the coding region (226 residues). A low level of aberrantly spliced transcript was identified in homozygous mutant mice by Northern blot analysis of total splenic RNA. (J:79254)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79254
Poss KD et al.,
"Heme oxygenase 1 is required for mammalian iron reutilization."
Proc Natl Acad Sci U S A 1997 Sep 30;94(20):10919-24
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All: |
34 reference(s)
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Analysis Tools
