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| Nomenclature |
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Symbol:
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Mat1atm1Jmm
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Name:
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methionine adenosyltransferase I, alpha;
targeted mutation 1, Jose M Mato
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MGI ID: |
MGI:2388143 |
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Gene:
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Mat1a
Location:
Chr14:41105381-41124412 bp, + strand
Genetic Position: Chr14,
22.36 cM, cytoband C1
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Liver histology from 8 month old Mat1atm1Jmm/Mat1atm1Jmm mice fed a normal diet
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69408
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 3 via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Northern and Western blot of liver RNA and proteins. (J:69408)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mat1a Mutation:
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2 strains or lines available |
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Notes |
Expression of Mat2a mRNA was induced 3-fold in homozygous mutant animals. Expression of Afp mRNA was also increased in homozygous mutants.
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| References |
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Original: |
J:69408
Lu SC et al.,
"Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation."
Proc Natl Acad Sci U S A 2001 May 8;98(10):5560-5
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All: |
7 reference(s)
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Analysis Tools
