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| Nomenclature |
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Symbol:
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Ikzf3tm1Kge
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Name:
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IKAROS family zinc finger 3;
targeted mutation 1, Katia Georgopoulos
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MGI ID: |
MGI:2388132 |
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Synonyms: |
Aio-, Aiodelta7-, Aiolos- |
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Gene:
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Ikzf3
Location:
Chr11:98464902-98546031 bp, - strand
Genetic Position: Chr11,
61.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50626
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 0.35 kb region of exon 7 including the 5' splice acceptor site was replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in homozygous mutant animals as demonstrated by Northern blot analysis of spleen, bone marrow, and thymus samples using probes to exons 1-6 and exon 7. Immunohistochemical analysis of spleen sections from 4 week old homozygous mutant mice did not detect protein product. (J:50626)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ikzf3 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:50626
Wang JH et al.,
"Aiolos regulates B cell activation and maturation to effector state."
Immunity 1998 Oct;9(4):543-53
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All: |
10 reference(s)
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Analysis Tools
