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| Nomenclature |
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Symbol:
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Pik3cdtm1Tnr
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Name:
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phosphatidylinositol 3-kinase catalytic delta polypeptide;
targeted mutation 1, Martin Turner
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MGI ID: |
MGI:2388047 |
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Synonyms: |
p110delta-, Pik3cdtm1Tnr |
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Gene:
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Pik3cd
Location:
Chr4:149649168-149702571 bp, - strand
Genetic Position: Chr4,
80.15 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79133
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Parent Cell Line:
| PC3 (ES Cell) |
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Strain of Origin:
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129S4/SvJae-Tg(Prm-cre)70Og
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Exons 1 through 9, encoding the first 490 amino acids, were deleted by homologous recombination of floxed selection genes followed by cre mediated excision in male germ cells. Targeting was done in PC3 ES cells which are homozygous for a protamine-cre transgene, Tg(Prm-cre)70Og, which expresses Cre recombinase only in halpoid spermatids. Normal protein was undetected by Western blot analysis of thymocytes obtained from homozygous mutant mice. (J:79133)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pik3cd Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:79133
Clayton E et al.,
"A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation."
J Exp Med 2002 Sep 16;196(6):753-63
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All: |
20 reference(s)
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Analysis Tools
