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| Nomenclature |
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Symbol:
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Tg(Plp)66Kan
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Name:
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transgene insertion 66, Klaus-Armin Nave
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MGI ID: |
MGI:2388028 |
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Synonyms: |
PLP-tg, PLP-tg66 |
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Transgene:
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Tg(Plp)66Kan
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The complete transcription unit of the mouse Plp gene, including 3.5 kb of 5' regulatory sequence was used to create this transgenic mouse. Lines 66 and 72 were generated (7 and 3 copies of the transgene respectively). Lines 66 and 72 were generated (7 and 3 copies of the transgene respectively). (J:17373)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
In addition to transgenic line 66, a second founder line (line 72) was also generated. Although similar phenotypic characteristics were observed between lines 66 and 72, the majority of the analysis was performed using line 66.
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| References |
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Original: |
J:17373
Readhead C et al.,
"Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage."
Neuron 1994 Mar;12(3):583-95
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All: |
17 reference(s)
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Analysis Tools
