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| Nomenclature |
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Symbol:
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Ksr1tm1Shaw
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Name:
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kinase suppressor of ras 1;
targeted mutation 1, Andrey S Shaw
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MGI ID: |
MGI:2387975 |
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Synonyms: |
KSR- |
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Gene:
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Ksr1
Location:
Chr11:79013440-79146407 bp, - strand
Genetic Position: Chr11,
46.74 cM, cytoband B5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75739
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The exon encoding the CA2 domain was replaced by a neomycin selection cassette inserted by homologous recombination. While RT-PCR demonstrated that the neo cassette could be excised, Western blot analysis using both amino and carboxy terminal antibodies showed an absence of both normal truncated protein. (J:75739)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ksr1 Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:75739
Nguyen A et al.,
"Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo."
Mol Cell Biol 2002 May;22(9):3035-45
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All: |
10 reference(s)
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Analysis Tools
