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| Nomenclature |
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Symbol:
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Clip2tm1.1Gal
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Name:
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CAP-GLY domain containing linker protein 2;
targeted mutation 1.1, Niels Galjart
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MGI ID: |
MGI:2387833 |
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Synonyms: |
CLIP-L |
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Gene:
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Clip2
Location:
Chr5:134489386-134552434 bp, - strand
Genetic Position: Chr5,
74.63 cM, cytoband G
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:78711
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: ES cells containing Cyln2tm1Gal were electroporated with a construct containing cre recombinase and a hygromycin resistance gene. Expression of cre resulted in the excision of the floxed region containing both previously inserted selection genes and exons 3 through 17. Neither normal transcript nor normal protein was detected in homozygous mutant mice by Northern and Western blot analyses. Recombination left the previously inserted lacZ gene in frame with the endogenous promoter, which drove its expression. (J:78711)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78711
Hoogenraad CC et al.,
"Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice."
Nat Genet 2002 Sep;32(1):116-27
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All: |
3 reference(s)
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Analysis Tools
