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| Nomenclature |
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Symbol:
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Sftpctm1Swg
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Name:
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surfactant associated protein C;
targeted mutation 1, Stephan W Glasser
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MGI ID: |
MGI:2387813 |
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Synonyms: |
SP-C(-) |
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Gene:
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Sftpc
Location:
Chr14:70520941-70524081 bp, - strand
Genetic Position: Chr14,
36.32 cM
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Airspace remodeling, stromal thickening and monocytic infiltration in the lungs of Sftpctm1Swg/Sftpctm1Swg mice
Show the 6 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69619
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 2. No mature mRNA was detected in homozygous mutant animals via Northern blot of lung tissue, but a faint band of smaller size was observed. RT-PCR and sequence analysis revealed the product was an alternatively spliced transcript from exon 1 to exon 3, bypassing exon 2. No protein product was detected in alveolar lavage from homozygous mutant animals. (J:69619)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sftpc Mutation:
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4 strains or lines available |
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Notes |
ES cell line = D3R.
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| References |
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Original: |
J:69619
Glasser SW et al.,
"Altered stability of pulmonary surfactant in SP-C-deficient mice."
Proc Natl Acad Sci U S A 2001 May 22;98(11):6366-71
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All: |
6 reference(s)
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Analysis Tools
