|
|
| Nomenclature |
|
Symbol:
|
Shhtm3Amc
|
|
Name:
|
sonic hedgehog;
targeted mutation 3, Andrew P McMahon
|
|
MGI ID: |
MGI:2387802 |
|
Synonyms: |
N-Shh, Shhn |
|
Gene:
|
Shh
Location:
Chr5:28456815-28467101 bp, - strand
Genetic Position: Chr5,
14.39 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:69771
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Single point mutation |
| |
|
Mutation details: A construct containing a nonsense mutation at cysteine codon 199 was inserted at the endogenous locus via homologous recombination. Termination of translation after glycine 198 putatively precludes autoproteolytic activity and the associated process in which a cholesterol, involved in cell surface tethering, is attached to glycine 198. (J:69771)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Shh Mutation:
|
21 strains or lines available |
|
| References |
|
Original: |
J:69771
Lewis PM et al.,
"Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1."
Cell 2001 Jun 1;105(5):599-612
|
|
All: |
2 reference(s)
|
|
Analysis Tools
