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| Nomenclature |
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Symbol:
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Prnptm2Edin
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Name:
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prion protein;
targeted mutation 2, Edinburgh University
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MGI ID: |
MGI:2387688 |
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Synonyms: |
mPrP0/0, NPU, PrnpEdbg, Prnp- Edinburgh, PrP- |
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Gene:
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Prnp
Location:
Chr2:131909928-131938429 bp, + strand
Genetic Position: Chr2,
64.07 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:20398
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette (under the control of a mouse metallothionein promoter) into exon 3. Northern blot analysis of brain mRNA from homozygous mutant animals did not detect gene transcript, but detected the neo transcript. Western blot of brain membrane fractions from homozygous animals further confirmed the null allele. (J:20398)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:20398
Manson JC et al.,
"129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal."
Mol Neurobiol 1994 Apr-Jun;8(2-3):121-7
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All: |
39 reference(s)
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Analysis Tools
