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| Nomenclature |
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Symbol:
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Fzd4tm1Nat
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Name:
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frizzled homolog 4 (Drosophila);
targeted mutation 1, Jeremy Nathans
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MGI ID: |
MGI:2387667 |
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Synonyms: |
fz4(-), Fz4lacZ |
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Gene:
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Fzd4
Location:
Chr7:89404366-89410110 bp, + strand
Genetic Position: Chr7,
49.32 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:70078
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A cassette containing lacZ and neo was inserted at the start codon of the endogenous locus via homologous recombination. The inserted sequences replaced all but the last 70 bp of the protein coding region. Expression of beta-galactosidase was visualized by X-gal staining. (J:70078)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:70078
Wang Y et al.,
"Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene."
J Neurosci 2001 Jul 1;21(13):4761-71
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All: |
8 reference(s)
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Analysis Tools
