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| Nomenclature |
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Symbol:
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Kif1btm1Noh
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Name:
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kinesin family member 1B;
targeted mutation 1, Nobutaka Hirokawa
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MGI ID: |
MGI:2387573 |
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Synonyms: |
kif1B- |
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Gene:
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Kif1b
Location:
Chr4:149176319-149307693 bp, - strand
Genetic Position: Chr4,
79.05 cM, cytoband E
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:69772
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encoding the ATP binding consensus P loop of the motor domain was replaced with a neomycin cassette by homologous recombination. Western blot analysis of brain crude extracts showed both the alpha and beta isoforms to be absent in homozygous mice. (J:69772)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kif1b Mutation:
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33 strains or lines available |
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| References |
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Original: |
J:69772
Zhao C et al.,
"Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta."
Cell 2001 Jun 1;105(5):587-97
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All: |
1 reference(s)
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Analysis Tools
