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| Nomenclature |
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Symbol:
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Tg(SERPINA1-cre/ERT)1Ipc
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Name:
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transgene insertion 1, I Pierre Chambon
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MGI ID: |
MGI:2387444 |
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Synonyms: |
alphaAT-cre-ERT, Tg(SERPINA1-cre/ESR1)1Ipc |
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Transgene:
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Tg(SERPINA1-cre/ERT)1Ipc
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgenic construct encodes a tamoxifen inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand binding domain, to drive expression in hepatocytes. The ligand binding domain posesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes. (J:69327)
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Recombinase activity
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:69327
Imai T et al.,
"Inducible site-specific somatic mutagenesis in mouse hepatocytes."
Genesis 2000 Feb;26(2):147-8
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All: |
2 reference(s)
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Analysis Tools
